Nutraceuticals：3(3) (2023)
The Marine Factor 3,5-Dihydroxy-4-methoxybenzyl Alcohol Represses Adipogenesis in
Mouse 3T3-L1 Adipocytes In Vitro: Regulating Diverse Signaling Pathways
Masayoshi Yamaguchi,Kenji Yoshiike, Hideaki Watanabe and Mitsugu Watanabe
Curr Mol Med：(2023)
The Marine Factor 3,5-dihydroxy-4-methoxybenzyl Alcohol Suppresses Cell Growth,
Inflammatory Cytokine Production, and NF-κB Signaling-enhanced Osteoclastogenesis in
In Vitro Mouse Macrophages RAW264.7 Cells
Masayoshi Yamaguchi, Kenji Yoshiike, Hideaki Watanabe, Mitsugu Watanabe
International Journal of Molecular Sciences：24(12) (2023)
A Pacific Oyster-Derived Antioxidant, DHMBA, Protects Renal Tubular HK-2 Cells
against Oxidative Stress via Reduction of Mitochondrial ROS Production and Fragmentation
Hsin-Jung Ho,Natsumi Aoki ,Yi-Jou Wu ,Ming-Chen Gao ,Karin Sekine ,Toshihiro
Sakurai ,Hitoshi Chiba ,Hideaki Watanabe ,Mitsugu Watanabe Shu-Ping Hui
Anticancer Drugs：33(5) (2022)
The marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol suppresses growth,
migration and invasion and stimulates death of metastatic human prostate cancer cells:
targeting diverse signaling processes
Masayoshi Yamaguchi, Kenji Yosiike, Hideaki Watanabe, Mitsugu Watanabe
The Journal of Japan Mibyou Association：27(1) (2021)
The effects of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA)- containing fraction
isolated from soft tissue of the Pacific oyster (Crassostrea gigas) on sleep
electroencephalogram in stressed rats
Mitsugu Watanabe, Katsuya Kuroki, Kenji Yoshiike and Narumi Aramaki
BIO Clinica：36(1) (2021)
Antioxidant in the brain and stress-relieving effects of an antioxidant (DHMBA)
Mitsugu Watanabe
Jpn Pharmacol Ther：48(11) (2020)
Effect of intake of jelly compounded with 3,5-dihydroxy-4-methoxybenzyl alcohol
(DHMBA)- containing supernatant extracted from soft tissue of the Pacific oyster
(Crassostrea gigas) on perception of stress and sleep quality in healthy working men and
women.
－Randomized, Double-blind, Placebo-controlled, Comparative Study－
Mitsugu Watanabe, Koki Tanio, Mitsuhisa Takahashi, Narumi Aramaki, Humitoshi Horie,
Jiro Saito
CMC Publishing Co.,Ltd. Development of Functional Foods for Anti-Fatigue,
Anti-Stress, and Improving Sleep Quality：187-197 (2020)
Fatigue-mitigating and stress-mitigating properties of fractions containing the
novel antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), isolated from soft tissue
of the Pacific oyster (Crassostrea Gigas), due to their antioxidant capacity.
Mitsugu Watanabe
The Journal of Japan Mibyou Association： 26(1) (2020)
Antioxidant and stress-mitigating properties of the antioxidant
3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) from soft tissue of the Pacific oyster
(Crassostrea gigas) in intracerebral oxidative stress-caused
hypothalamo-hypophysealadrenal facilitated mouse
Mitsugu Watanabe, Takayuki Watanabe,
Jpn Pharmacol Ther : 46(3) , 2018
Effect of intake of jelly compounded with 3,5-dihydroxy-4-methoxybenzyl alcohol
(DHMBA)-containing supernatant extracted from soft tissue of the Pacific oyster
(Crassostrea gigas) on fatigue in healthy middle-aged men and women. －Randdomized,
Double-blind, Placebo-controlled, Comparative Study－
Mitsugu Watanabe, Emiko Miki, Er Jin Eio, Mitsuhisa Takahashi, Riko Fukuda.
Journal of Functional Foods: 35, 2017
Comparison of chemical structures and cytoprotection abilities between direct and
antioxidants.
Joko S., Watanabe M., Fuda H., Takeda S., Furukawa T., Hui S.P., Shrestha R., and Chiba H.
Jpn Pharmacol Ther : 45(2), 2017
Effects of intake of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA)-containing oyster extract
drink on the status of stress, fatigue, and sleep: a randdomized, double-blind,
placebo-controlled, parallel-group study.
Watanabe M, Miki E, Watanabe T, Katagiri M, Fukuda R, Urade Y.
Jpn Pharmacol Ther : 45(1), 2017
Antioxidant and stress-mitigating properties of the phenoloic antioxidant
3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), isolated from soft tissue of the Pacific
oyster (Crassostrea Gigas), in a mouse model of oxidative stress.
Watanabe M, Miki E, Urade Y.
Journal of Functional Foods: 20, 2016
Oyster extracts attenuate pathologial changes in non-alcoholic steatohepatitis (NASH) mouse
model.
Watanabe M., Fuda H., Okabe H., Joko S., Miura Y., Hui S.P., Yimin, Hamaoka N., Miki E., and
Chiba H.
Food Chemistry： vol.176, 2015
Anti-apoptitic effects of novel phenolic antioxidant isolated from the Pacific Oyster
(Crassostrea Gigas) on cultured human hepatocytes under oxidative stress.
Fuda H., Watanabe M., Hui S.P., Joko S., Okabe H., Jin S., Takeda S., Miki E., Watanabe T.,
and Chiba H.
284-292,CMC (2013)
Feeding trial to evaluate usefulness of functional food materials in humans
Mitsugu WATANABE
Food Chemistry： vol.134 issue4, 2012
A phenolic antioxidant from the Pacific oyster (Crassostrea Gigas) inhibits
oxidation of cultured human hepatocytes mediated by diphenyl-1-Pyrenylphosphine
Mitsugu WATANABE, Hirotoshi FUDA, Shigeki JIN, Toshihiro SAKURAI, Shu-Ping HUI, Seiji TAKEDA,
Takayuki WATANABE, Takao KOIKE, Hitoshi CHIBA
Journal of Agricultural and Food Chemistry： vol.60 No.3, 2012
Isolation and characterization of a phenolic antioxidant from the Pacific Oyster
(Crassostrea Gigas)
Mitsugu WATANABE, Hirotoshi FUDA, Shigeki JIN, Toshihiro SAKURAI, Futaba OHKAWA, Shu-Ping
HUI, Seiji TAKEDA, Takayuki WATANABE, Takao KOIKE, and Hitoshi CHIBA
Japanese Journal of Health Promotion： Vol.14 No.1, 2012
Effect of the food containing oyster extract on stress, fatigue, quality of sleep and
quality of life in working persons
Mitsugu WATANABE, Tetsuro YAMAMOTO, Chang Hua HUANG, Hisayoshi OKAMURA, Akira TSUDA
Neurochemistry International ：Vol.56 No.3 2010
Susceptibility to stress in young rats after 2-week zinc deprivation
Mitsugu WATANABE, Haruna TAMANO, Toshinori KIKUCHI, Atsushi TAKEDA
Clinical Pharmacology and Therapy：Vol.20 No.6 2010
Clinical efficacy of Watanebe Active Oyster on sperm profiles in healthy male subjects.
Mitsugu
Progress in Medicine： Vol.29 No.3 2009
Zinc supplementary and anti-oxidative effects of Oyster extract-containing diet in patients
with Type 2 diabetes mellitus
Mitsugu WATANABE, Tetsuro YAMAMOTO, and Hideyo YAMAGUCHI
Progress in Medicine： Vol.29 No.2 2009
Beneficial effect of Oyster extract-containing diet in patients with recurrent aphthous
stomatitis
Mitsugu WATANABE, Tetsuro YAMAMOTO, Ichiro SAITO, Hideyo YAMAGUCHI
